Monday, October 21, 2019
Session I - Mechanisms
Carin Marcy Barth, Chair
Welch Foundation Board of Directors
Jennifer A. Doudna, University of California, Berkeley
Welch Foundation Scientific Advisory Board Member
Session Leader: Samuel H. Sternberg, Columbia University
Speaker: Taekjip Ha, Johns Hopkins University
Lecture: "CRISPR and DNA Repair"
Speaker: Stephen Kowalczykowski, University of California, Davis
Lecture: "Watching and Understanding DNA Recombination and Replication, One Molecule at a Time"
Speaker: Martin Jinek, University of Zurich
Lecture: "Structural and Mechanistic Insights into CRISPR-Cas Genome Editors"
Session II - Applications
Session Leader: David Taylor, The University of Texas at Austin
Speaker: Jonathan Weissman, University of California, San Francisco
Lecture: "Manifold Destiny: Exploring Genetic Interactions in High Dimensions through Massively Parallel Single Cell RNA-seq"
Speaker: Jay Shendure, University of Washington
Lecture: "Multiplex Genome Editing for Variant Interpretation and Developmental Recording"
Speaker: Niren Murthy, University of California, Berkeley
Lecture: "Therapeutic Gene Editing Enabled by New Drug Delivery Vehicles"
Tuesday, October 22, 2019
Session III - Imaging
Session Leader: Ke Xu, University of California, Berkeley
Speaker: Alice Ting, Stanford University
Lecture: "Molecular Tools for Probing RNA Localization and Interactions in Living Cells"
Speaker: Xiaowei Zhuang, Harvard University
Lecture: "Imaging at the Genomic-Scale: From 3D Organization of the Genomic DNA to Cell Atlas of Complex Tissues"
Speaker: Ernest Laue, University of Cambridge
Lecture: "Single Cell Hi-C and Single Molecule Imaging to Study Nuclear Architecture"
2019 Welch Award Lecture
Session IV - Alternatives/Future Directions
Session Leader: Alexis Komor, University of California, San Diego
Speaker: Akihiko Kondo, Kobe University
Lecture: "Genome Editing with Base Editing Systems from Bacteria to Plant"
Speaker: David R. Liu, Harvard University
Lecture: "Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells"
Speaker: Kira Makarova, National Institutes of Health
Lecture: "Comparative Genomics Perspective on Discovery and Functional Diversity of CRISPR-cas Systems"