2019 Welch Conference on Chemical Research
"The Chemistry of Genome Editing and Imaging"
Hilton Houston North Hotel, Houston, Texas
October 21-22, 2019
Jennifer A. Doudna
We are in the midst of a revolution in our ability to query and alter genetic material. Basic research uncovered CRISPR-Cas9 and related enzymes as tools for genome editing, paving the way for both fundamental and applied research and applications. Our first session will examine genome editing enzymes and the chemistry behind targeted genome manipulation.
As all of life is based upon the building blocks of DNA, this technology are profound and far-reaching, including research inmicrobes, plants, insects and mammals. Our second session will focus on translational work that is adapting and developing genome editing platforms for use in the clinic, in fields, and in labs around the world.
Understanding genome function and evolution requires determining chromosome spatio-temporal organization. Innovations in imaging are yielding new insights into the where and when of CRISPR-Cas enzyme binding and cleavage of DNA within the complex 3D structures inside the nucleus, the focus of our third session.
Finally, the fourth session is about future directions of genome engineering, including innovations such as base editing that make direct chemical changes to DNA sequences without DNA cleavage. The chemistry of genome editing and imaging will provide a foundation for future discovery and technology development in this exciting field.
Monday, October 21, 2019
Session I + II
Tuesday, October 22, 2019
Session III + IV