Monday, October 21, 2019

Session I - Mechanisms

8:30 AM

Introductory Remarks

Carin Marcy Barth, Chair
Welch Foundation Board of Directors

8:35 AM

Conference Introduction

Jennifer A. Doudna, University of California, Berkeley
Welch Foundation Scientific Advisory Board Member

8:40 AM

Session Leader: Samuel H. Sternberg, Columbia University

8:50 AM

Speaker: Taekjip Ha, Johns Hopkins University
Lecture: "CRISPR and DNA Repair"

9:40 AM

Speaker: Stephen Kowalczykowski, University of California, Davis
Lecture: "Watching and Understanding DNA Recombination and Replication, One Molecule at a Time"

10:45 AM

Speaker: Martin Jinek, University of Zurich
Lecture: "Structural and Mechanistic Insights into CRISPR-Cas Genome Editors"

Session II - Applications

1:00 PM

Session Leader: David Taylor, The University of Texas at Austin

1:10 PM

Speaker: Jonathan Weissman, University of California, San Francisco
Lecture: "Manifold Destiny:  Exploring Genetic Interactions in High Dimensions through Massively Parallel Single Cell RNA-seq"

2:00 PM

Speaker: Jay Shendure, University of Washington
Lecture: "Multiplex Genome Editing for Variant Interpretation and Developmental Recording"

3:05 PM

Speaker: Niren Murthy, University of California, Berkeley
Lecture: "Therapeutic Gene Editing Enabled by New Drug Delivery Vehicles"

Tuesday, October 22, 2019

Session III - Imaging

8:00 AM

Session Leader:  Ke Xu, University of California, Berkeley

8:10 AM

Speaker: Alice Ting, Stanford University
Lecture: "Molecular Tools for Probing RNA Localization and Interactions in Living Cells"

9:00 AM

Speaker: Xiaowei Zhuang, Harvard University
Lecture: "Imaging at the Genomic-Scale:  From 3D Organization of the Genomic DNA to Cell Atlas of Complex Tissues"

10:00 AM

Speaker: Ernest Laue, University of Cambridge
Lecture: "Single Cell Hi-C and Single Molecule Imaging to Study Nuclear Architecture"

2019 Welch Award Lecture

10:50 AM

Speaker: TBN
Lecture: "TBD"

Session IV - Alternatives/Future Directions

1:05 PM

Session Leader: Alexis Komor, University of California, San Diego

1:15 PM

Speaker: Akihiko Kondo, Kobe University
Lecture: "Genome Editing with Base Editing Systems from Bacteria to Plants"

2:05 PM

Speaker: David R. Liu, Harvard University
Lecture: "Base Editing:  Chemistry on a Target Nucleotide in the Genome of Living Cells"

3:05 PM

Speaker: Kira Makarova, National Institutes of Health
Lecture: "Comparative Genomics Perspective on Discovery and Functional Diversity of CRISPR-Cas Systems"